Treosulfan

The Method of Administration and Posology

Depending on the blood count and concurrent chemotherapy, 3-8g/m2 i.v. should be administered every 1-3 weeks. Also, no adverse side effects have been seen after single injections of up to 8gm/2 have been administered. Intraperitoneal doses of up to 1.5g/m2 have been administered too. As a bolus injection, up to 3g/m2 doses may be given. Every 5-10 minutes, larger doses of 3g/m2 may be administered as I .v. infusion.

Points to Note

In case the white blood cell count is below 3.000/microlite or if the count of a thrombocyte is less than 100.000/microlite, the treatment should be avoided. If other cytotoxic drugs are being given or radiotherapy is being administered, Treosulfan should be given only in lower doses.

Extravasation into the tissues should be avoided at all costs so that no pain and tissue damage is caused. In the case of extravasation, the medicine should immediately be discontinued and the medicine left should be introduced to a separate vein.

Dosage

As Treosulfan is excreted really, the blood count should be monitored consistently in the elderly and the dosage should be adjusted accordingly. It’s not to be used in children.

Caution

The administration of Treosulfan raises the chances of infection, mycotic, bacterial or viral. There may be contraindications like-

• Patients being hypersensitive to the active substance
• Bone marrow depression that’s severe and lasting

While transfusion, a flawless technique should be used to avoid painful inflammatory reactions.